Shares of Surrozen Inc. (Nasdaq: SRZN), which just filed a statement with the Securities and Exchange Commission (SEC), were up 10.26% at $0.52 at the time of the last check in after-hours trading.
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What kind of SEC filing has SRZN made?
In its filing with the SEC on December 9, 2022, Surrozen (SRZN) disclosed that it is finding and developing biologic therapeutic candidates to specifically control the Wnt pathway, a key mediator of tissue repair, in a variety of organs and tissues, for human disorders. Surrozen has made ground-breaking discoveries that, in its opinion, will overcome previous constraints in utilizing the full potential of Wnt biology. These discoveries build upon the pioneering study of its founding members and scholarly experts who revealed the Wnt gene and crucial regulators of the Wnt pathway.
What strategy has SRZN chosen?
These advancements allowed SRZN to quickly and adaptably create tissue-specific medicines that regulate Wnt signaling. As a result of its breakthroughs, SRZN is setting the bar for tissue-specific Wnt candidates, creating and manufacturing Wnt pathway mimics, and selective stimulation of Wnt signaling.
By identifying disease states susceptible to Wnt regulation, developing tissue-specific therapies, and advancing prospects into new therapeutic in focused indications with significant unmet needs, the SRZN method aims to fully use Wnt signaling. Two lead product candidates have been found and advanced by SRZN thanks to its distinctive strategy and platform technology.
Updates from SRZN include
Following the observation of treatment-related adverse events, SRZN voluntarily suspended recruitment in the single ascending dose, or SAD, as part of its Phase 1 clinical study investigating SZN-1326 in healthy volunteers in November 2022. A number of individuals, including three with grade 3 ALT and AST increases, had asymptomatic liver transaminase elevations.
A status report on the continuing SAD part of the SZN-043 study with healthy volunteers was also given by SRZN in November 2022. Several SZN-043-dosed participants had grade 1 and 2 treatment-related, asymptomatic liver transaminase increases.
How is SRZN changing things?
The core product candidates for Surrozen (SRZN) are antibody-based multi-specific therapies that imitate the functions of naturally occurring Wnt or R-spondin proteins, which, respectively, are involved in activating or enhancing the Wnt pathway. Surrozen has the potential to treat a wide range of serious disorders, including some that affect the retina, gut, liver, cornea, kidney, lung, cochlea, skin, central nervous system, and pancreas. Wnt signaling is crucial for tissue maintenance and regeneration throughout the body. Each of them, according to SRZN, has the potential to alter the disease’s treatment paradigm and have a significant influence on patient outcomes.
